Samuel H H Chan Selected Research

Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)

9/2016	Sumoylation of IkB attenuates NF-kB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death.
3/2014	Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication.
2/2014	Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-κB activation-induced nitric oxide synthase II expression.
12/2012	Brain stem oxidative stress and its associated signaling in the regulation of sympathetic vasomotor tone.
1/2011	A double-edged sword role for ubiquitin-proteasome system in brain stem cardiovascular regulation during experimental brain death.
7/2010	Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus.
4/2009	Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus.
4/2007	Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia.
9/2005	Nitric oxide- and superoxide-dependent mitochondrial signaling in endotoxin-induced apoptosis in the rostral ventrolateral medulla of rats.
7/2005	In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOS II/peroxynitrite cascade.

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Samuel H H Chan Research Topics

Disease

19	Hypertension (High Blood Pressure) 01/2019 - 05/2002
17	Hypotension (Low Blood Pressure) 07/2022 - 03/2003
10	Endotoxemia 09/2016 - 01/2002
8	Status Epilepticus (Complex Partial Status Epilepticus) 12/2016 - 10/2004
7	Bradycardia 05/2007 - 03/2003
6	Mitochondrial Diseases (Mitochondrial Disease) 07/2022 - 10/2004
5	Brain Death (Brain Dead) 09/2016 - 01/2011
4	Hypoxia (Hypoxemia) 03/2011 - 04/2005
3	Heart Failure 01/2017 - 02/2010
3	Cardiovascular Diseases (Cardiovascular Disease) 12/2015 - 06/2006
3	Seizures (Absence Seizure) 03/2012 - 04/2009
2	Acute Liver Failure (Fulminant Hepatic Failure) 07/2022 - 12/2017
2	Stroke (Strokes) 07/2021 - 06/2019
2	Edema (Dropsy) 06/2019 - 12/2017
2	Organophosphate Poisoning 01/2018 - 05/2007
2	Coma (Comas) 09/2016 - 01/2011
2	Poisoning 03/2014 - 05/2007
2	Inflammation (Inflammations) 09/2012 - 01/2012
1	Hepatic Encephalopathy 07/2022
1	Cerebral Infarction 07/2021
1	Hypercapnia 01/2021
1	Hypoventilation 01/2021
1	Respiratory Acidosis 01/2021
1	Ischemic Stroke 06/2019
1	Infarction (Infarctions) 06/2019
1	Kidney Diseases (Kidney Disease) 01/2018
1	Neoplasms (Cancer) 12/2015
1	Carcinogenesis 01/2015
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2014

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 07/2022 - 09/2002
13	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 09/2016 - 03/2003
12	LipopolysaccharidesIBA 09/2012 - 09/2002
11	Superoxides (Superoxide)IBA 11/2013 - 05/2003
11	EnzymesIBA 04/2012 - 01/2002
9	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 06/2006
8	Peroxynitrous Acid (Peroxynitrite)IBA 12/2017 - 07/2005
8	Nitric Oxide Synthase (NO Synthase)IBA 10/2014 - 12/2004
6	AntioxidantsIBA 01/2019 - 06/2006
6	Cytochromes c (Cytochrome c)IBA 07/2012 - 01/2002
5	Messenger RNA (mRNA)IBA 07/2022 - 02/2004
5	MevinphosIBA 01/2018 - 04/2005
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2012 - 12/2004
5	Superoxide DismutaseIBA 01/2012 - 09/2005
5	Propofol (Diprivan)FDA LinkGeneric 05/2007 - 07/2003
4	Oxygen (Dioxygen)IBA 07/2021 - 01/2011
4	Caspase 3 (Caspase-3)IBA 06/2019 - 04/2007
4	coenzyme Q10 (CoQ10)IBA 10/2014 - 05/2003
3	Adenosine Triphosphate (ATP)IBA 07/2022 - 04/2005
3	NF-kappa B (NF-kB)IBA 09/2016 - 12/2004
3	Oxidoreductases (Dehydrogenase)IBA 12/2015 - 01/2002
3	tempolIBA 10/2014 - 09/2005
3	OrganophosphatesIBA 03/2014 - 04/2005
3	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 02/2014 - 01/2003
3	NADPH Oxidases (NAD(P)H oxidase)IBA 10/2013 - 02/2009
3	CytokinesIBA 10/2013 - 10/2003
3	UbiquitinIBA 04/2012 - 01/2011
3	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 03/2011 - 02/2004
3	CaspasesIBA 04/2007 - 10/2003
2	Pharmaceutical PreparationsIBA 01/2018 - 01/2012
2	Neuroprotective AgentsIBA 12/2016 - 05/2003
2	quinone (benzoquinone)IBA 12/2015 - 05/2003
2	Angiotensin IIIBA 11/2013 - 10/2013
2	AngiotensinsIBA 10/2013 - 07/2003
2	Transcription Factors (Transcription Factor)IBA 10/2013 - 12/2004
2	Methamphetamine (Desoxyn)FDA LinkGeneric 12/2012 - 01/2012
2	C-Reactive ProteinIBA 09/2012 - 01/2012
2	Uncoupling Protein 2IBA 07/2012 - 10/2009
2	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 04/2012 - 01/2011
2	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2012 - 01/2011
2	OligonucleotidesIBA 01/2012 - 07/2005
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2012 - 10/2010
2	Heme Oxygenase-1IBA 03/2011 - 12/2009
2	CatalaseIBA 02/2009 - 06/2006
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2009 - 06/2006
2	Dizocilpine Maleate (Dizocilpine)IBA 10/2006 - 05/2002
2	6-Cyano-7-nitroquinoxaline-2,3-dione (6 Cyano 7 nitroquinoxaline 2,3 dione)IBA 10/2006 - 05/2002
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 04/2005 - 01/2002
2	NAD (NADH)IBA 10/2004 - 01/2002
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2022
1	AzoxymethaneIBA 07/2022
1	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 07/2021
1	Glucose (Dextrose)FDA LinkGeneric 06/2019
1	triphenyltetrazoliumIBA 06/2019
1	PesticidesIBA 01/2018
1	AmmoniaIBA 12/2017
1	Thioacetamide (Thioacetamid)IBA 12/2017
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2017
1	Dynamins (Dynamin)IBA 12/2016
1	Prorenin ReceptorIBA 02/2015
1	Phosphotransferases (Kinase)IBA 01/2015
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2015
1	Small Interfering RNA (siRNA)IBA 10/2014
1	FructoseIBA 10/2014
1	Pioglitazone (Actos)FDA Link 10/2014

Therapy/Procedure

7	Intravenous Administration 04/2012 - 05/2003
4	Anesthesia 05/2007 - 04/2004
3	Therapeutics 01/2019 - 01/2012
2	Catheters 08/2011 - 07/2005
1	Intraperitoneal Injections 07/2022
1	Spinal Anesthesia 07/2021